Tissue reconstruction using cell sheet engineering and its application to regenerative medicine

DOI 3 Citations
  • HARAGUCHI Yuji
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
  • SHIMIZU Tatsuya
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
  • YAMATO Masayuki
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
  • KIKUCHI Akihiko
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
  • OKANO Teruo
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University

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  • 細胞シート工学を用いた組織再構築および再生医療への応用

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Recently, regenerative medicine is considered one of the most promising treatments for defective or damaged tissues. Cell-based therapies have been clinically performed for some tissues. And more recently, advanced therapies have shifted towards tissue engineering using biodegradable scaffolds. Cooperation between life science and engineering has led to rapid progress in tissue engineering. On the other hand, we have developed novel technology “cell sheet engineering”, which can avoid the limitations of single cell suspension injection or tissue reconstruction using biodegradable scaffolds. We aim to reconstruct various tissues using cell sheet engineering and apply the technology to regenerative medicine. Clinical trials have been performed for some tissues and significant improvement can be observed.

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