Superhydrophilicity Promotes Cell Proliferation

DOI 3 Citations
  • YOSHINARI Masao
    Department of Dental Materials Science, Tokyo Dental College
  • MATSUZAKA Kenichi
    Department of Clinical Pathophysiology, Tokyo Dental College
  • INOUE Takashi
    Department of Clinical Pathophysiology, Tokyo Dental College
  • ODA Yutaka
    Department of Dental Materials Science, Tokyo Dental College
  • SHIMONO Masaki
    Department of Pathology, Oral Health Science Center, Tokyo Dental College
  • HAYAKAWA Tohru
    Department of Dental Materials, Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo

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  • 超親水性表面は骨芽細胞の増殖を促進する

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A thin-film coating of hexamethyldisiloxane (HMDSO) and an O2-plasma treatment were carried out on titanium (Ti) plates. The contact angle of HMDSO-coatings without O2-plasma treatment against double-distilled water was more than 100 degrees, and dramatically decreased after the O2-plasma treatment with less than 5 degrees, resulting superhydrophilicity. Cell proliferation and the alkaline-phosphatase activity of osteoblast-like cells increased on the surfaces of HMDSO-coating with O2-plasma treatment compared to on the Ti and HMDSO-coatings without O2-plasma treatment. SEM observation revealed that the cultured cells were spread on O2-plasma modified surfaces. These results indicated that HMDSO-coating with O2-plasma treatment was a promising for fabricating with osteogenesis surface of scaffolds.

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