Recent Progress in Multiple Endocrine Neoplasia Type 2

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  • 多発性内分泌腫瘍症2（Multiple endocrine neoplasia type 2：MEN2）医療の進歩
  • タハツセイ ナイブンピ シュヨウショウ 2(Multiple endocrine neoplasia type 2 : MEN2) イリョウ ノ シンポ

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Abstract

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal, predominantly hereditary disease characterized by medullary thyroid carcinoma, pheochromocytoma, and primary hyperparathyroidism; it is classified into type 2A, type 2B, and familial medullary thyroid carcinoma (FMTC). The last decade has seen improvements in the treatment and management of MEN2 in Japan. The establishment of a Japanese MEN database and the publication of a MEN clinical guidebook have played an important role in promoting effective management of the disease in our country. Our knowledge of MEN2 has expanded greatly, and in this review, I summarize our understanding of the disease based on recent discoveries.

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