An Osteoblast Differentiation Promoting Compound, TAK-778, combined with β-Tricalcium Phosphate used for Packing Interbody Fusion Cages
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- Ohyama Takashiro
- Department of Neurosurgery, Mie University School of Medicine
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- Kubo Yoshichika
- Department of Neurosurgery, Neuroscience Center, Sakakibaraonsen Hospital
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- Iwata Hiroo
- Department of Reparative Materials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University
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- Taki Waro
- Department of Neurosurgery, Mie University School of Medicine
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説明
A synthetic 3-benzothiepin derivative, TAK-778, promotes osteoblast differentiation. If a mixture of TAK-778 and β-tricalcium phosphate (β-TCP) can be a substitute for autografts used for packing interbody fusion cages, donor-site related complications should be avoided. The lumbar vertebrae from L1 to L5 were exposed in 8 dogs using a posterolateral approach, and discectomy and interbody cage fusion were performed in three disc spaces. In group A, the cage was filled with autograft bone, in group B with β-TCP, and in group C with β-TCP and TAK-778. The lumbar spine was excised at 16 weeks post-surgery, and mechanical, microradiographical and histological evaluations were made. The microradiographical and histological examinations revealed four fusions in eight operations in group A (50.0%), three in group B (37.5%), and five in group C (62.5%). The mean percentage of trabecular bone area in the cages was 53.4% in group A, 45.6% in group B and 64.4% in group C. Although the effect was not significant, addition of TAK-778 to β-TCP had some beneficial influence and there was a trend toward an improved fusion status in cages filled with β-TCP and TAK-778. β-TCP combined with TAK-778 could be used as a substitute for autografts in clinical spine surgery, especially for those patients who are anticipated to have a poor graft bone status.
収録刊行物
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- 脊髄外科
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脊髄外科 17 (3), 183-194, 2003
日本脊髄外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282680207941248
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- NII論文ID
- 110002953570
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- NII書誌ID
- AN10283463
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- ISSN
- 18809359
- 09146024
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 使用不可