Involvement of descending monoaminergic systems in antiallodynic effect of goshajinkigan in oxaliplatin-treated mice
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- Kitamura Ryo
- Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences
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- Andoh Tsugunobu
- Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences
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- Fushimi Hirotoshi
- Museum of Materia Medica, Research Center for Ethnomedicine, Institutes of Natural Medicine
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- Komatsu Katsuko
- Division of Pharmacognosy, Institutes of Natural Medicine
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- Shibahara Naotoshi
- Division of Kampo Diagnostics, Institutes of Natural Medicine, University of Toyama
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- Kuraishi Yasushi
- Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences
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説明
Oxaliplatin, a key chemotherapeutic drug, frequently causes peripheral neuropathy accompanied by pain and allodynia. A few recent clinical studies showed that a traditional herbal formulation goshajinkigan (GJG) prevents oxaliplatin-induced neuropathy. In this study, we examined the mechanisms underlying acute antiallodynic activity of GJG in mice with oxaliplatin-induced neuropathy. A single intraperitoneal injection of oxaliplatin (3 mg/kg) induced mechanical allodynia, which peaked at day 10 after injection and subsided almost completely by day 18. On day 10 after oxaliplatin injection, oral administration of GJG (0.3 and 1.0 g/kg, but not 0.1 g/kg) inhibited established mechanical allodynia after oxaliplatin administration. The inhibitory effect peaked 30 min after GJG administration and subsided by 2 h. The antiallodynic activity of GJG was inhibited by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine (20 μg/site) and the serotonergic neurotoxin 5,7-dihydroxytryptamine (20 μg/site). Administration of GJG (1.0 g/kg) to oxaliplatin-treated mice showed no effect on the levels of noradrenaline, serotonin, 3-methoxy-4-hydroxyphenylglycol (a noradrenaline metabolite), and 5-hydroxyindoleacetic acid (a serotonin metabolite). These results suggest that the descending noradrenergic and serotonergic systems are involved in GJG-mediated inhibition of oxaliplatin-induced mechanical allodynia.
収録刊行物
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- Journal of Traditional Medicines
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Journal of Traditional Medicines 30 (4), 183-189, 2013
和漢医薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282680209827328
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- NII論文ID
- 130004942434
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- NII書誌ID
- AA12035198
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- ISSN
- 18813747
- 18801447
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- NDL書誌ID
- 025042902
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可