Pharmacological analysis for the optimal combination<BR>ratio of Shakuyaku and Kanzo in Shakuyakukanzoto

DOI Web Site 11 References
  • ENDO Mari
    Oriental Medicine Research Center of The Kitasato Institute
  • OIKAWA Tetsuro
    Oriental Medicine Research Center of The Kitasato Institute
  • NUNOME Shinyu
    Oriental Medicine Research Center of The Kitasato Institute Graduate School of Pharmaceutical Sciences, Kitasato University
  • YAMADA Haruki
    Oriental Medicine Research Center of The Kitasato Institute Graduate School of Pharmaceutical Sciences, Kitasato University Kitasato Institute for Life Sciences, Kitasato University
  • HANAWA Toshihiko
    Oriental Medicine Research Center of The Kitasato Institute Graduate School of Medical Science, Kitasato University

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  • Pharmacological analysis for the optimal combination ratio of Shakuyaku and Kanzo in Shakuyakukanzoto

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Abstract

Shakuyakukanzoto(SKT) consists of two kinds of crude drugs, Shakuyaku and Kanzo. SKT is used for leg cramps, stomachache, and menstrual colic pain. Clinically, different combination ratios of Shakuyaku and Kanzo exists, including the use of Kagenho (modified formulations) of an other Kampo formulation. But it remains un clear which ratio is best to apply.<BR>We investigated the best combination ratio of Shakuyaku and Kanzo using mouse for the estimation of intestinal tract movement. SKT composed of Shakuyaku 50% and Kanzo 50% significantly decreased intestinal tract movement, comparable to atropin. These data suggest that these combination ratios of Shakuyaku and Kanzo work best for suppressing peristaltic motion.<BR>In this study, we demonstrated that the combination ratio of Shakuyaku and Kanzo used as the formulation is reasonable from the standpoint of pharmacological background.

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