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Effects of Kampo medicines on Cyp3a and P-glycoprotein activity in vivo
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- ITO Kiyomi
- Department of Clinical Pharmacokinetics, Hoshi University
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- TAKASAKI Ayaka
- Department of Clinical Pharmacokinetics, Hoshi University
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- IKARASHI Nobutomo
- Department of Clinical Pharmacokinetics, Hoshi University
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- WATANABE Junko
- TSUMURA Research Laboratories, Tsumura & Co.
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- KANITANI Masanao
- TSUMURA Research Laboratories, Tsumura & Co.
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- SUGIYAMA Kiyoshi
- Department of Clinical Pharmacokinetics, Hoshi University
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Description
In order to evaluate the possibility of Kampo medicines causing pharmacokinetic drug-drug interactions, the effects of 3 Kampo medicines (rikkunshito, yokukansan and boiogito) on the activities of cytochrome P450 (CYP) and P-glycoprotein (P-gp) were investigated in a mouse in vivo study using triazolam and digoxin, respectively, as probe substrates.<BR>A significant increase in the plasma triazolam concentration was observed by co-administration of ketoconazole, a Cyp3a inhibitor, whereas none of the Kampo medicines tested showed any significant effects on triazolam pharmacokinetics in mice. Similarly, plasma concentration of digoxin was significantly elevated by quinidine co-administration, while unaffected by any of the Kampo medicines investigated.<BR>These findings indicate that rikkunshito, yokukansan and boiogito are unlikely to affect the pharmacokinetics of co-administered drugs which are substrates of CYP3A and/or P-gp.
Journal
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- Journal of Traditional Medicines
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Journal of Traditional Medicines 26 (3), 131-135, 2009
Medical and Pharmaceutical Society for WAKAN-YAKU
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Details 詳細情報について
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- CRID
- 1390282680210172544
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- NII Article ID
- 130004495541
- 110007356319
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- NII Book ID
- AA12035198
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- ISSN
- 18813747
- 18801447
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- NDL BIB ID
- 10435107
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- CiNii Articles
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- Abstract License Flag
- Disallowed