Development of an <I>in vivo</I> assay method for evaluation of "oketsu" using hen-egg white lysozyme (HEL)-induced blood flow decrease

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  • IWAOKA Emiko
    Department of Pharmacy, Hyogo University of Health Sciences
  • OKU Hisae
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
  • ISHIGURO Kyoko
    School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University

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  • Development of an in vivo assay method for evaluation of "oketsu" using hen-egg white lysozyme (HEL)-induced blood flow decrease

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Abstract

"Oketsu", or stagnant blood syndrome, is one of the important pathological concepts in therapy with Kampo formula and drugs. Here we show the effectiveness of our previously developed in vivo assay system for the evaluation of such drugs. The assay system measures blood flow in the microcirculation of the mouse tail after injection of hen-egg white lysozyme (HEL). The results showed the effectiveness of Kampo formula and crude drugs clinically used to treat "oketsu", while little effect was found with drugs used for other purposes. These results indicated the effectiveness of the method for screening drugs aimed at "oketsu" treatment.

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