Preventive effects of Daisaikoto on metabolic disorders in spontaneous obese type II diabetes mice

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  • TSUNAKAWA Mitsuo
    Department of Medicinal Informatics, Graduate School of Medical Science, Kanazawa University
  • SHIMADA Tsutomu
    Research Institute of Pharmaceutical Sciences, Musashino University
  • SUZUKI Wataru
    Research Institute of Pharmaceutical Sciences, Musashino University
  • NAGATA Mitsunobu
    Research Institute of Pharmaceutical Sciences, Musashino University
  • TAKEDA Shuichi
    Research Institute of Pharmaceutical Sciences, Musashino University
  • MIZUNO Asako
    Research Institute of Pharmaceutical Sciences, Musashino University Department of Veterinary, Nippon Veterinary and Life Science University
  • KOSUGI Mitsutaka
    Research Institute of Pharmaceutical Sciences, Musashino University
  • ABURADA Masaki
    Research Institute of Pharmaceutical Sciences, Musashino University

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  • Preventive effects of Daisaikoto on metabolic disorders in spontaneous obese type 2 diabetes mice

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Metabolic syndrome (MS) is one of the syndromes known as an underlying lifestyle-related diseases. Recently, the number of obese people keeps on increasing, and visceral fat accumulation has been reported as the most important risk factor for the development of MS. In this study, the effects of Daisaikoto, a Kampo preparation, on metabolic disorders were investigated using TSOD mice, an animal model of spontaneous obese type II diabetes.<BR>Four-week-old TSOD mice that had not yet developed obesity and TSNO mice that do not develop metabolic disorders were given ad libitum powder feed containing Daisaikoto at a concentration of 1% or 3% for 2 months. After 2 months, the control TSOD mice developed various metabolic disorders such as marked obesity and visceral fat accumulation, increase of the blood glucose level, the insulin level, T-Cho level, TG level and LDL level, abnormal glucose tolerance, hypertension and neuropathy as distinct from the control TSNO mice. In the TSOD mice treated with Daisaikoto, the body weight gain and visceral fat accumulation were suppressed, and the abnormal glucose tolerance, elevation of blood pressure and peripheral neuropathy were also significantly suppressed. On the other hand, in TSNO mice, Daisaikoto showed no noteworthy impacts on most parameters. The above results suggested that Daisaikoto would be effective for the prevention against various symptoms of MS.

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