Experimental Study on a Novel Chemical Application Procedure for <i>in Vitro</i> Skin Corrosivity Testing Using the Vitrolife-Skin<sup>TM</sup> Human Skin Model
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- Morikawa Noriyuki
- Division of Research & Development, GUNZE Ltd.
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- Morota Katsuyasu
- Division of Research & Development, GUNZE Ltd.
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- Suzuki Masakazu
- Division of Research & Development, GUNZE Ltd.
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- Kojima Hajime
- Research Laboratories, Nippon Menard Cosmetic Co., Ltd.
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- Nakata Satoru
- Research Laboratories, Nippon Menard Cosmetic Co., Ltd.
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- Konishi Hiroaki
- Research Laboratories, Nippon Menard Cosmetic Co., Ltd.
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説明
During the last decade, ECVAM has supported formal validation studies on in vitro tests for predicting skin corrosivity, which included two of the in vitro tests employed human skin models, EPISKINTM and EpiDermTM. When skin models are used to evaluate skin irritancy and corrosivity, it is important that suitable chemical application procedures are utilized. We used several chemicals and evaluated their skin corrosivity using in vitro tests, evaluations using ECVAM experimental protocols and post-incubation methods that we have originally developed to predict skin irritancy, and compared the results. Vitrolife-Skin showed basic utility for corrosivity testing by both methods and it is possible to confidently predict skin corrosivity, provided that the appropriate chemical application procedures are used. In the future, human skin models will become very useful for purposes of predicting in vivo skin corrosivity of chemicals and for studying the mechanistic aspects of such corrosivity.
収録刊行物
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- Alternatives to Animal Testing and Experimentation
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Alternatives to Animal Testing and Experimentation 11 (1), 68-78, 2005
日本動物実験代替法学会
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詳細情報 詳細情報について
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- CRID
- 1390282680210566912
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- NII論文ID
- 10021094523
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- NII書誌ID
- AA11161787
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- ISSN
- 21854726
- 13440411
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
