Hepatoprotective activity of <I>Eclipta prostrata</I> L<SUB>INN</SUB>. extract in ethanol induced rat hepatic injury
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- PRAMYOTHIN Pornpen
- Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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- TUNGKASEN Hatairuk
- Pharmacological Action of Natural Products Research Unit, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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- POUNGSHOMPOO Somlak
- Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University
Bibliographic Information
- Other Title
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- Hepatoprotective activity of Eclipta prostrata L[INN.] extract in ethanol induced rat hepatic injury
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Abstract
This study was undertaken to investigate the hepatoprotective activity of Eclipta prostrata LINN. (EP) in ethanol induced rat hepatic injury. In the in vitro study, EP (0.1, 0.2, 0.3 mg/ml) increased % MTT reduction and decreased the release of transaminases (ALT and/or AST) in rat primary cultured hepatocytes being treated with ethanol. Hepatotoxic markers studied in rats included serum transaminases (ALT and AST), serum triglyceride (STG), hepatic triglyceride (HTG), TNF-α and IL-1β together with histopathological examination. Pretreatment of rats with EP at oral dose of 10, 20, 30 mg/kg and silymarin (a reference hepatoprotective agent) at 5 mg/kg 4 h before ethanol (5 g/kg, p.o.) decreased the ethanol induced levels of ALT and/or AST. The 30 mg/kg EP dose gave the best result similar to SL. Treatment of rats with EP (30 mg/kg/day) or SL (5 mg/kg/day) for 7 days after 21 days with ethanol (4 g/kg/day, p.o.) enhanced liver cell recovery by bringing the levels of ALT, AST and IL-1β back to normal. Histopathological observations confirmed the beneficial roles of EP and SL against ethanol induced liver injury in rats. Possible mechanism may involve their antioxidant activity.
Journal
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- Journal of Traditional Medicines
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Journal of Traditional Medicines 24 (5), 164-167, 2007
Medical and Pharmaceutical Society for WAKAN-YAKU
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Details 詳細情報について
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- CRID
- 1390282680210611328
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- NII Article ID
- 130004495500
- 110006437773
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- NII Book ID
- AA12035198
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- ISSN
- 18813747
- 18801447
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- NDL BIB ID
- 9263660
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed