Enamine-Based Reactions: Strategies for the Development of Organocatalysts and Catalyzed Reactions

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  • Tanaka Fujie
    Institute for Chemical Research, Kyoto University Faculty of Engineering, Gifu University

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  • エナミン機構に基づく反応：有機分子触媒の開発と反応の工夫
  • エナミン キコウ ニ モトズク ハンノウ ユウキ ブンシ ショクバイ ノ カイハツ ト ハンノウ ノ クフウ

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Abstract

Enamines are key intermediates in both organic chemistry and enzyme catalysis. We have developed designer proteins and small peptides that catalyze aldol, retro-aldol, and Michael reactions, in which catalyst molecules form enamines from aldehydes and ketones in situ. We have also developed small amine- and amino acid-catalyzed enamine-based bond-forming reactions that can be performed under mild conditions. In this review, I summarize our strategies for the development of designer catalysts and catalyzed reactions that use enamines as key intermediates.

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