Effects of the herbal medicine hochuekkito on semen parameters and seminal plasma cytokine levels (TNF-α , IL-6, RANTES) in idiopathic male infertility

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  • AKASHI Takuya
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
  • WATANABE Akihiko
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
  • MORII Akihiro
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
  • MIZUNO Ichiro
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
  • FUSE Hideki
    Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

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  • Effects of the herbal medicine hochuekkito on semen parameters and seminal plasma cytokine levels TNF a IL 6 RANTES in idiopathic male infertility

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Abstract

This study was conducted to evaluate the effects of hochuekkito on semen parameters, and to clarify the relationships among IL-6, TNF-α, RANTES, and semen parameters in idiopathic male infertility. Twenty patients with idiopathic oligozoospermia and/or asthenozoospermia (<20 x 10 6/ml and/or 50%) were given 7.5 g of herb daily for 3 months. Before and immediately after the final treatment, semen analysis and measurements of seminal plasma cytokines were performed. Seminal plasma levels of IL-6, TNF-α , and RANTES were analyzed by enzyme-linked immunosorbent assays. Sperm motility was significantly increased after herb administration (p<0.002); however, semen volume, sperm count, and normal morphology did not change. The seminal plasma level of RANTES was decreased after treatment (p<0.024); however, the seminal plasma levels of TNF-α and IL-6 were unchanged. Hochuekkito may influence the concentrations of certain cytokines in seminal plasma.

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