Determination of Optimal Cut-off Points for Obesity-related Measures of Metabolic Syndrome Based on Insulin Resistance
-
- Chizumi Yamada
- Department of Clinical Health Science, Tokai University School of Medicine
-
- Toshitake Mitsuhashi
- Department of Clinical Health Science, Tokai University School of Medicine
-
- Noboru Hiratsuka
- Department of Clinical Health Science, Tokai University School of Medicine Shinjuku Center Bldg. Clinic
-
- Fumiyo Inabe
- Department of Clinical Health Science, Tokai University School of Medicine
-
- Nami Araida
- Department of Clinical Health Science, Tokai University School of Medicine
-
- Eiko Takahashi
- Department of Clinical Health Science, Tokai University School of Medicine
この論文をさがす
抄録
Background The aim of the present study was to determine the cut-off points for obesity-related measures based on insulin resistance, which contributes to the clustering of borderline risk factors in the early stage of metabolic syndrome (MetS).<br>Methods We determined the cut-off points of waist circumference (WC), BMI, and percentage of body fat (%fat) in 2129 men and 1879 women by receiver operating characteristics (ROC) analysis to predict homeostasis model assessment of insulin resistance (HOMA-IR) ≥2.5, and compared them with cut-offs in current use and those determined by linear regression corresponding to HOMA-IR=2.5. We then compared diagnostic efficiency in predicting insulin resistance among WC, BMI, and %fat.<br>Results ROC analysis yielded cut-off points of WC 88 cm and 82 cm, BMI 25 kg/m2 and 23 kg/m2 , and %fat 24% and 29% for men and women, respectively. The cut-off points derived from ROC had better diagnostic efficiency than those from linear regression or currently used values. WC, BMI, and %fat appeared to be equivalent in the diagnosis of obesity in early-stage MetS, as shown by comparable values for area under the curve and 95% CI.<br>Conclusion The optimal cut-off points for predicting insulin resistance were determined as WC 88 cm and 82 cm, BMI 25kg/m2 and 23 kg/m2, and %fat 24% and 29% for men and women, respectively. (Ningen Dock 2011; 25: 53-59)
収録刊行物
-
- 人間ドック(Ningen Dock)
-
人間ドック(Ningen Dock) 25 (6), 53-59, 2011
公益社団法人 日本人間ドック学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282680211701504
-
- NII論文ID
- 10031145771
-
- NII書誌ID
- AA12055286
-
- ISSN
- 21865027
- 18801021
-
- NDL書誌ID
- 11062629
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可