Insulin Secretory Response to Oral Glucose in Subjects with Normal Glucose Intolerance

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  • OGTTで正常型と判定された症例のインスリン動態について
  • OGTT デ セイジョウガタ ト ハンテイ サレタ ショウレイ ノ インスリン ドウタイ ニ ツイテ

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Objective: The purpose of this retrospective cohort study was to evaluate the immunoreactive insulin (IRI) response during a 75g oral glucose tolerance test (OGTT) in subjects with a normal OGTT pattern. <br>Methods: Out of 1,036 persons who underwent the OGTT, 680 with a normal OGTT pattern were enrolled in the present study. Persons enrolled were classified into 2 categories: normal IRI response pattern with IRI level peaking at 30 min; delayed IRI response pattern with IRI level peaking after 30 min. <br>Results: Of the 680 subjects, 280 (41.2%) had the normal IRI response pattern, and 400 (58.8%) had the delayed IRI response pattern. The delayed IRI response pattern exhibited increased fasting plasma glucose (FPG) and 1-h plasma glucose (PG), elevated homeostasis model assessment-insulin resistance (HOMA-IR), and a decreased 30-min insulinogenic index (I.I.)(p<0.001).<br>Conclusion: The present study indicates that a delayed IRI response pattern is related to FPG, 1h-PG, HOMA-IR, and I.I..

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