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Insulin Secretory Response to Oral Glucose in Subjects with Normal Glucose Intolerance
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- Tanabe Maho
- Health Management Center, Toranomon Hospital
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- Arase Yasuji
- Health Management Center, Toranomon Hospital
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- Tsuji Hiroshi
- Health Management Center, Toranomon Hospital
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- Shiun Dong Hsieh
- Health Management Center, Toranomon Hospital
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- Ohmoto Yuki
- Health Management Center, Toranomon Hospital
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- Amakawa Kazuhisa
- Health Management Center, Toranomon Hospital
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- Kato Hisahito
- Health Management Center, Toranomon Hospital
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- Arimoto Satao
- Health Management Center, Toranomon Hospital
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- Okuda Chikao
- Health Management Center, Toranomon Hospital
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- Ogawa Kyoko
- Health Management Center, Toranomon Hospital
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- Iwao Akiko
- Health Management Center, Toranomon Hospital
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- Hashimoto Mitsuyo
- Health Management Center, Toranomon Hospital
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- Yotsukura Yoshie
- Health Management Center, Toranomon Hospital
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- Miyakawa Megumi
- Health Management Center, Toranomon Hospital
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- Hara Shigeko
- Health Management Center, Toranomon Hospital
Bibliographic Information
- Other Title
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- OGTTで正常型と判定された症例のインスリン動態について
- OGTT デ セイジョウガタ ト ハンテイ サレタ ショウレイ ノ インスリン ドウタイ ニ ツイテ
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Description
Objective: The purpose of this retrospective cohort study was to evaluate the immunoreactive insulin (IRI) response during a 75g oral glucose tolerance test (OGTT) in subjects with a normal OGTT pattern. <br>Methods: Out of 1,036 persons who underwent the OGTT, 680 with a normal OGTT pattern were enrolled in the present study. Persons enrolled were classified into 2 categories: normal IRI response pattern with IRI level peaking at 30 min; delayed IRI response pattern with IRI level peaking after 30 min. <br>Results: Of the 680 subjects, 280 (41.2%) had the normal IRI response pattern, and 400 (58.8%) had the delayed IRI response pattern. The delayed IRI response pattern exhibited increased fasting plasma glucose (FPG) and 1-h plasma glucose (PG), elevated homeostasis model assessment-insulin resistance (HOMA-IR), and a decreased 30-min insulinogenic index (I.I.)(p<0.001).<br>Conclusion: The present study indicates that a delayed IRI response pattern is related to FPG, 1h-PG, HOMA-IR, and I.I..
Journal
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- Official Journal of Japan Society of Ningen Dock
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Official Journal of Japan Society of Ningen Dock 26 (4), 601-606, 2011
Japan Society of Ningen Dock
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Details 詳細情報について
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- CRID
- 1390282680211987456
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- NII Article ID
- 10031145810
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- NII Book ID
- AA12055286
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- ISSN
- 21865027
- 18801021
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- NDL BIB ID
- 023466770
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL Search
- CiNii Articles
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- Abstract License Flag
- Disallowed