Detection of Metabolic Syndrome and Its Reserve Group in Outpatients Received Medical Screening for Health, and Significance of Measurement on Insulin Resistance

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  • Makino Isao
    Department of Medical examination for health, Megumino Hospital
  • Nakamura Miho
    Department of Medical examination for health, Megumino Hospital
  • Ishikawa Yoshio
    Department of Medical examination for health, Megumino Hospital
  • Adachi Susumu
    Department of Medical examination for health, Megumino Hospital
  • Ikeda Masato
    Department of Medical examination for health, Megumino Hospital
  • Kato Junji
    Department of Medical examination for health, Megumino Hospital
  • Ishida Makiko
    Department of Medical examination for health, Megumino Hospital
  • Kondoh Hiroshi
    Department of Medical examination for health, Megumino Hospital

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Other Title
  • 人間ドックでのメタボリックシンドロームおよび予備群の検出とインスリン抵抗性測定の意義
  • ニンゲン ドック デノ メタボリック シンドローム オヨビ ヨビグン ノ ケンシュツ ト インスリン テイコウセイ ソクテイ ノ イギ

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Objective: By Ministry of Health Labour and Welfare, it has been shown that one of two in Japanese male, while one of five in Japanese female, is either MS or reserve subject (MS candidate). However, there is a little study about pathogenesis of reserve subjects, then we aimed to investigate about their insulin resistance. Methods: The 386 outpatients (262 men and 124 women) who received medical screening for health (Ningen Dock) at Megumino Hospital from October 2005 to May 2006 were used to this present study. These outpatients were devided into three groups: MS, reserve and noncorrespond group. Added to routine examinations, Homeostasis model assessment of insulin resistance (HOMA-R) was determined. Results: Of male patients, MS group was 17%, reserve group25% and noncorrespond group 58%. Average value of HOMA-R in three groups 3.00,2.12 and 1.32, and the appearance rate of abnormally increased HOMA-R 48%,25% and 12%, in order. Of female, MS was 3%, reserve 13% and noncorrespod 84%. Average value of HOMA-R 3.88,2.36 and 1.07, and the appearance rate of abnormally increased resistance 75%,31% and 10% in order. The data indicates that an increase of insulin resitance occurs already at the stage of reserve group, and is enhanced following progress into MS. (Conclusion): In order to promote preventation of MS, it could be important to pick up not only MS group but also reserve group, and to try reduction of insulin resistannce.

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