Development and Evaluation of Improved Challenge Diet Intended to Lighten Burden of Subjects

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  • 被験者への負荷軽減を目的とした改良糖負荷試験食の開発と性能評価
  • ヒケンシャ エ ノ フカ ケイゲン オ モクテキ ト シタ カイリョウ トウ フカ シケンショク ノ カイハツ ト セイノウ ヒョウカ

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Abstract

Objective: The standard cookie test, an existing challenge diet, is characterized by the difficulty of completely ingesting all the cookies within a particular time frame. We devised an improved challenge diet in which the number of cookies is decreased and an amount of powdered sugar equivalent to the reduction in carbohydrate content is dissolved in sugar-free tea. We evaluated the effectiveness of our improved challenge diet by comparing its glycemic pattern with existing challenge diets, as well as from the responses of subjects to a questionnaire.<br> Methods: We recruited ten volunteers who had not been previously diagnosed with diabetes and whose fasting blood glucose level was ≥ 90 mg/dL at the most recent health check-up. Trelan-G®, a cookie test, and our improved challenge diet were administered at 1-week intervals. Blood sampling was performed at 0, 30, 60, and 120 minutes after administration to measure parameters related to sugar and lipid metabolism.<br> Results: Blood sugar and insulin patterns following administration of our new challenge diet were similar to those of Trelan-G and glucose intolerance could also be detected using 1-hour plasma glucose with the new diet (concordance rate: 9/9). Blood lipid levels increased after the new diet and the questionnaire revealed that the difficulty of subjects in complying with it was reduced compared with the cookie test.<br> Conclusion: We confirmed that our new challenge diet maintained a constant level of performance and that it reduced the burden on subjects. This challenge diet could be useful for the early detection of glucose intolerance and/or postprandial hyperlipidemia during a routine health check-up.

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