Longitudinal Study on Pulmonary Function and Smoking Habit in Subjects Undergoing Health Check-ups

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  • 人間ドック受診者における呼吸機能と喫煙習慣に関する縦断的検討
  • ニンゲン ドック ジュシンシャ ニ オケル コキュウ キノウ ト キツエン シュウカン ニ カンスル ジュウダンテキ ケントウ

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Objective: We examined an association between longitudinal change in pulmonary function and smoking habit in health check-ups.<br>Methods: Our subjects were 4,178 individuals (2,969 males, 1,209 females) aged from their 30s to their 60s who underwent a health check-up at our health check-up center in both 2008 and 2013. We investigated associations between one-second forced expiratory volume (FEV1), longitudinal change in FEV1 and FEV1%, and smoking habit, no smoking period and smoking amount.<br>Results: FEV1 and FEV1% were lower in male smokers and longitudinal decline in FEV1 was significantly greater in smokers than in former smokers and non-smokers. Although no significant differences in FEV1 and FEV1% were observed for smokers in the 30s age group, there were significant declines in these parameters in smokers as compared to former smokers and non-smokers in the 40s, 50s and 60s age groups. Regarding subjects who were smokers in 2008, longitudinal declines in FEV1 for those who continued smoking and those who quit smoking by 2013 were 34.4 mL/year and 23.6 mL/year, respectively, with the decline in continuing smokers being significant. As for FEV1%, the difference between the former smokers and non-smokers disappeared after more than 5 years and FEV1% was significantly higher than in the smokers group.<br>Conclusion: FEV1 and FEV1% decreased with smoking and there was a large decline in FEV1 over time. However, in people in their 50s and 60s, the decline in pulmonary function can be reduced by stopping smoking.

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