Clinical Characteristics of a Japanese Subpopulation with Low Plasma Free Essential and Semi-essential Amino Acid Levels

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  • Imaizumi Akira
    Institute for Innovation, Ajinomoto, CO., Inc
  • Nagao Kenji
    Institute for Innovation, Ajinomoto, CO., Inc
  • Jinzu Hiroko
    Institute for Innovation, Ajinomoto, CO., Inc
  • Tanaka Takayuki
    Institute for Innovation, Ajinomoto, CO., Inc
  • Kageyama Yoko
    Institute for Innovation, Ajinomoto, CO., Inc
  • Yamamoto Hiroshi
    Institute for Innovation, Ajinomoto, CO., Inc
  • Toda Akiko
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
  • Tani Mizuki
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
  • Ishizaka Yuko
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
  • Yamakado Minoru
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital Department of Nursing, Ashikaga Institute for Technology

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Other Title
  • 日本人における必須・準必須アミノ酸濃度の低値者の臨床的特徴
  • ニホンジン ニ オケル ヒッス ・ ジュンヒッス アミノサン ノウド ノ テイチシャ ノ リンショウテキ トクチョウ

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Objective: Plasma free amino acid (PFAA) profiles indicate a person’s health with regard to nutritional status and disease risks. In this study, we investigated the clinical characteristics of a Japanese subpopulation with low plasma free essential and semi-essential amino acid levels.<br>Methods: Plasma free essential and semi-essential amino acids were quantified in a total of 10,102 Japanese subjects who underwent a full health check-up. Low plasma amino acid levels were defined as lower than mean - 2×SD (standard deviation) after conversion to standardized values. Then, associations between low plasma free essential and semi-essential amino acid levels and deviations from health indicator reference ranges were analyzed.<br>Results: Among the 10,102 subjects, 16.6% were classified as the low plasma free essential and semi-essential amino acid levels subpopulation, whose subjects had low levels of one or more plasma free essential and semi-essential amino acids. In this subpopulation, the proportion of subjects who were outside the reference ranges for protein nutrition was significantly higher than in the rest of the subjects. Furthermore, the rates for subjects who were outside the reference ranges for indicators related to various conditions including anemia, cardiovascular diseases and infectious diseases were significantly higher in this subpopulation.<br>Conclusion: The findings of this study suggest that profiles of plasma free essential and semi-essential amino acids could be a beneficial surrogate marker for health risks associated with reduced quality of life (QOL).

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