Relationship between Plasma Glucose Levels and Blood Pressure in Individuals with Normal Fasting Plasma Glucose

DOI Web Site

Bibliographic Information

Other Title
  • 空腹時血糖正常者における血糖と血圧の関係
  • クウフクジ ケットウ セイジョウシャ ニ オケル ケットウ ト ケツアツ ノ カンケイ

Search this article

Abstract

Objective: The aim of this study was to explore an association between fasting plasma glucose (FPG) and blood pressure in individuals with normal FPG levels.<br>Methods: Among those who were not taking antihypertensive, antihyperlipidemic, or antihyperuricemic agents, we retrospectively investigated 1,114 subjects with FPG < 100ml/dL and HbA1c < 5.6% in a general health check-up. Various parameters, including age, gender, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), uric acid (UA), estimated glomerular filtration rate (eGFR), smoking habit, alcohol intake, and familial history of hypertension and diabetes, were evaluated. On the basis of the FPG levels, the subjects were categorized into the following tertiles: T1 (62 mg/dL ≤ FPG < 90 mg/dL, n = 398), T2 (90 mg/dL ≤ FPG < 95 mg/dL, n = 356), and T3 (95 mg/dL ≤ FPG < 100 mg/dL, n = 360).<br>Results: Univariate analysis on the total number of subjects revealed that age, gender, BMI, WC, TC, TG, LDL-C, UA, and FPG were positively correlated with SBP and DBP. On the other hand, HDL-C and eGFR were negatively correlated with SBP and DBP. Stepwise linear regression analysis showed that FPG was significantly and independently correlated with SBP and DBP. Furthermore, despite adjusting for confounding variables, the SBP and DBP levels of T2 and T3 subjects were significantly higher than those of T1 subjects.<br>Conclusion: FPG levels were found to be a key determinant of blood pressure in subjects with normal FPG.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top