Commensal microbiota-derived signals regulate host immune system through epigenetic modifications
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- Takahashi Daisuke
- Division of Developmental Immunology, La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA
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- Hase Koji
- Department of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan
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説明
Commensal microbiota colonizing the digestive tract is a symbiotic partner of its host, as it plays a critical role in nutrient metabolism as well as the development and maturation of the host immune system. Although it is clear that regulation of the host-commensal relationship is crucial to mammalian health, the underlying mechanisms regulating gut homeostasis are yet to be elucidated. Epigenetic modifications, including DNA methylation and histone methylation/acetylation, alter the structure of chromatin to regulate the transcriptional program of eukaryotic cells. At the whole genome level, these modifications possibly play a key role in regulating the mutually beneficial relationship between the host and the gut microbiota. In this review, we describe how the commensal microbiota and its metabolic by-products modify the epigenome of host cells, and in turn, change their development and functional behavior.
収録刊行物
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- Inflammation and Regeneration
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Inflammation and Regeneration 35 (3), 129-136, 2015
一般社団法人 日本炎症・再生医学会
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詳細情報 詳細情報について
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- CRID
- 1390282680233258112
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- NII論文ID
- 130005078577
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- ISSN
- 18808190
- 18809693
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
