Application of Decoy Oligodeoxynucleotides for Arthritis
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- Tomita Tetsuya
- Department of Orthopaedics, Osaka University Graduate School of Medicine
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- Kunugiza Yasuo
- Department of Orthopaedics, Osaka University Graduate School of Medicine Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine
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- Tomita Naruya
- Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School
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- Kuroda Shoko
- Department of Orthopaedics, Osaka University Graduate School of Medicine Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine
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- Morishita Ryuichi
- Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine
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- Yoshikawa Hideki
- Department of Orthopaedics, Osaka University Graduate School of Medicine
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Abstract
Recent progress in DNA technologies has provided the strategies to regulate the transcription of disease-related genes in vivo using antisense oligodeoxynucleotide (ODN). Transfection of cis-element double-stranded oligodeoxynucleotides (decoy ODNs) has been reported as a new therapeutic tool of anti-gene strategies for gene therapy. In the field of arthritis, decoy ODNs strategies have been significant therapeutic potential. The concept of regulation the disease related gene expression at the level of transcriptional factor may be more therapeutic effects compared with monotherapy in arthritis.
Journal
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- Inflammation and Regeneration
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Inflammation and Regeneration 26 (6), 507-512, 2006
The Japanese Society of Inflammation and Regeneration
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Details 詳細情報について
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- CRID
- 1390282680234018688
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- NII Article ID
- 10026499883
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- NII Book ID
- AA11508953
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- ISSN
- 18808190
- 18809693
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- NDL BIB ID
- 8685316
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed