Epidermal regeneration by keratinocyte-alien mesenchymal cell interactions

DOI Web Site 被引用文献1件 参考文献34件
  • Aoki Shigehisa
    Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga, Japan
  • Kitajima Yoshihiko
    Department of Surgery, Faculty of Medicine, Saga University, Saga, Japan
  • Takezawa Toshiaki
    Transgenic Animal Research Center, National Institute of Agrobiological Sciences, Ibaraki, Japan
  • Uchihashi Kazuyoshi
    Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga, Japan
  • Matsunobu Aki
    Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga, Japan
  • Sugihara Hajime
    Department of Pathology, International University of Health and Welfare, Fukuoka, Japan
  • Toda Shuji
    Department of Pathology & Microbiology, Faculty of Medicine, Saga University, Saga, Japan

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説明

Mesenchymal support plays crucial roles in both normal and cancer tissue development. In the skin, dermal mesenchymal fibroblasts provide keratinocytes with many cytokines as critical crosstalk molecules through epithelial-mesenchymal interactions. A number of reports have demonstrated that mesenchymal stem cells and myofibroblasts participate in skin repair. Although the importance of both mesenchymal support and the mesenchymal cell phenotype has been recognized, the relationship between the mesenchymal cell phenotype and the paracrine/autocrine action remains unclear. Moreover, the organ that supplies these supportive mesenchymal cell types within the injured tissue is still unclear. In the skin, it is also unknown whether non-skin organ-derived mesenchymal cells, other than the bone marrow and adipose tissue, affect epidermal regeneration through mesenchymal-epithelial interactions. Here, we highlight recent findings regarding the paracrine/autocrine action and phenotypic characters of non-skin-derived mesenchymal cells. We also briefly present our preliminary data regarding the supporting effect of cancer-associated fibroblasts on normal tissue repair.

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