Hypersensitivity of a Urate-null Strain of Drosophila melanogaster to the Toxic Effects of Environmental Cigarette Smoke

DOI Web Site 被引用文献3件 参考文献35件
  • Hamatake Yuko
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Morita Ayumi
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Yuma Yoko
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Okamoto Keinosuke
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Arimoto Sakae
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Suzuki Toshinori
    School of Pharmacy, Shujitsu University
  • Kasai Hiroshi
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • Kawai Kazuaki
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • Negishi Tomoe
    Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University

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説明

Epidemiological evidence indicates that cigarette smoke is harmful to human health. Mainstream cigarette smoke has already been demonstrated to induce tissue and cellular damage in animal models. In the present study, we examined the toxicity of environmental cigarette smoke (ECS) by exposing Drosophila melanogaster larvae from urate-null and wild-type strains to ECS for 3 or 6 h at the third instar stage. We then determined survival to adulthood and the fecundity of adult females that survived larval ECS exposure. The survival of the urate-null strain, but not the wild-type strain, decreased significantly in an exposure-dependent manner. Moreover, the fecundity of treated urate-null, but not wild-type, females decreased significantly relative to the control level, irrespective of mating partner exposure to ECS at the larvae stage. These results demonstrate the killing effect and reproductive toxicity of ECS on urate-null larvae of Drosophila. Since the urate-null strain is known to be sensitive to oxidative agents, we propose that the main cause of the observed toxic effects of ECS is oxidative stress.<br>

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