Isolation of “Oryzanin” (Antineuritic Vitamin) from Rice-polishings. (Second Report.)

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  • OHDAKE SATOR
    Agricultural Chemical Laboratory, Tokyo Imperial University

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(1) The hydrochloride of oryzanin which was prepared in pure state directly from so-called “ Oryzanin-extract” by silver-fractionation, platinum precipitation in alcohol and repeated recrystallisation from alcohol and acetone, possessed entirely the same properties with that purified further through picrolanate and chloraurate. The analytical results agree with the formula C12H16N4SO2-2HCl which was given by the author in the previous report. The yield: 1.6g. from 11.500kg. of rice-polishings.<br> (2) The hydrochloride cured and protected pigons as well as albinorats from polyneuritis with the daily dose of 0.005_??_0.01mg. The curative day-dose for a pigeon was found to be the order of 0.0025mg.<br> (3) Besides the hydrochloride, the author prepared the picrolonate (C12H16N4SO2-2C10H8N4O5 M.Pt. 226°C), the picrate (C12H16N4SO2 2C6H3N3O7 M.Pt. 208°C), the chloraurate (C12H16N4SO2-2HAuCl4 M.Pt. 189°C) the chlor-platinate (C12H16N4SO2-H2PtCl6) and finally the free base (amorphous), and studied their properties.<br> (4) From these results, it was confirmed that the antineuritic substance isolated from rice-polishings by the author, is a new sulphur compound having the empirical formula C12H16N4SO2.<br> Further studies on the chemical constitution of this substance will be reported later on.<br> The author expresses his sincere thanks to Prof. Dr. U. Suzuki for his kind advise and encouragement throughout the work. Thanks are due to Sankyo Company, Ltd. for kind supply of the material. The author is also indebted to Messrs M. Kamada and T. Yamagishi for their assistance both in chemical and biological experiments.<br> (May 12 th., 1932).

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詳細情報 詳細情報について

  • CRID
    1390282680234363008
  • NII論文ID
    130003415047
  • DOI
    10.1271/bbb1924.8.111
  • ISSN
    18811272
    03758397
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
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    使用不可

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