Evaluation of Viscoelastic Property of Articular Cartilage Based on Mechanical Model Considering Tissue Microstructure

DOI Web Site 被引用文献1件 参考文献16件 オープンアクセス
  • OSAWA Takako
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
  • MATSUMOTO Takeshi
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
  • NAITO Hisashi
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
  • TANAKA Masao
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University

書誌事項

公開日
2012
DOI
  • 10.1299/jbse.7.31
公開者
一般社団法人 日本機械学会

説明

The mechanical behavior of articular cartilage is strongly dependent on its microstructure characterized by three-dimensional, depth-dependent densities and anisotropic arrangements of cartilage cells and collagen fibres in extracellular matrix. The inclusion of cartilage microstructure to model analysis is essential for the accurate evaluation of the mechanical property. This study proposes a model-based evaluation method, which could predict tissue microstructure (collagen fibres, proteoglycans, and cartilage cells) based on a time history of reaction force obtained from indentation test, thereby estimating the depth-dependent cartilage mechanical property that is difficult to be estimated by experiment in conventional methods. The model was used for evaluating the viscoelasticities of cartilage at medial (load-supporting) and lateral (non load-supporting) regions on bovine femoral head. The present simulation allows fitting the time-history of reaction force measured from indentation test (R2 = 0.993 ± 0.0012 for lateral region and R2 = 0.990 ± 0.0032 for medial region). The differences of the elastic modulus of collagen fibre and the permeability between medial and lateral regions were consistent to those observed from the chemical composition analysis.

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