Influence of Processing after Harvesting and Cultivation Year on the Components of Scutellariae Radix (<i>Scutellaria baicalensis</i> Georgi) and Inhibitory Effect of Their Constituents on Nitric Oxide Production

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  • Fuchino Hiroyuki
    Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition
  • Arai Ryoko
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Tanaka Manami
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Kinoshita Koutaro
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Daikonya Akihiro
    Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition
  • Wada Hiroshi
    Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • Kumagai Takeo
    Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition
  • Kawahara Nobuo
    Research Center for Medicinal Plant Resources, National Institutes of Biomedical Innovation, Health and Nutrition

Bibliographic Information

Other Title
  • オウゴンの加工調製法ならびに栽培年数が成分に与える影響と一酸化窒素産生抑制活性について
  • オウゴン ノ カコウ チョウセイホウ ナラビニ サイバイ ネンスウ ガ セイブン ニ アタエル エイキョウ ト イッサンカ チッソ サンセイ ヨクセイ カッセイ ニ ツイテ

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Abstract

<p>This paper describes the influence of post-harvest processing and the cultivation year on the components of the root of Scutellaria baicalensis Georgi. The major flavonoid glycosides of Scutellariae Radix extract, baicalin and wogonoside were reduced by drying at high temperatures. The glycosides were also enzymatically hydrolyzed and C-glycoside was stable under any drying condition. Flavonoid glycosides were stored in the thin part of two-year-old roots and the bold part of one- and three-year-old roots, whereas aglycones were preserved in the bold part of two-year-old roots. However, in the freeze-dried samples unaffected by temperature and enzymatic activity, the glycosides were found in the bold roots and aglycones were found in the thin roots as expected. Furthermore, analysis of eight isolated compounds showed that wogonoside, wogonin and baicalein had potent inhibitory effects on NO production.</p>

Journal

  • Shoyakugaku Zasshi

    Shoyakugaku Zasshi 70 (1), 1-9, 2016

    The Japanese Society of Pharmacognosy

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