Measurement of Erythrocyte Deformability by Uniaxial Stretching
-
- KOHRI Shimpei
- Department of Medical Engineering, Aino University
-
- KATO Yousuke
- Graduate School of Science and Engineering, Kansai University
-
- TAJIKAWA Tsutomu
- Department of Mechanical Engineering, Faculty of Engineering Science, Kansai University
-
- YAMAMOTO Yasufumi
- Department of Mechanical Engineering, Faculty of Engineering Science, Kansai University
-
- BANDO Kiyoshi
- Department of Mechanical Engineering, Faculty of Engineering Science, Kansai University
Bibliographic Information
- Other Title
-
- 単軸引張によるヒト赤血球の変形能の測定
- 単軸引張によるヒト赤血球の変形能の測定 : 見かけのヤング率と形状回復時定数の測定
- タンジク ヒッパリ ニ ヨル ヒト セッケッキュウ ノ ヘンケイノウ ノ ソクテイ : ミカケ ノ ヤングリツ ト ケイジョウ カイフク ジテイスウ ノ ソクテイ
- —見かけのヤング率と形状回復時定数の測定—
- —Measurement of Apparent Young's Modulus and Time Constant of Shape Recovering—
Search this article
Abstract
An erythrocyte can be deformed very easily by even very small amounts of stress, enabling it to flow smoothly through approximately 3 µm diameter microvessels despite its larger size of 8 µm in diameter and 2 µm in thickness. Reduction of erythrocyte deformability leads to poor circulation particularly in microvessels, which may result in hypertension and various circulatory diseases. To clarify blood microcirculatory properties, it is very important to understand the deformability of erythrocytes. However, a standard method for quantitative evaluation of erythrocyte deformability has not yet been established. In this study, an apparent Young's modulus and a time constant for the recovery of erythrocyte shape following uniaxial stretching are proposed as deformability indices. When an erythrocyte was pulled horizontally on opposite ends using two micropipettes, tensile stress and strain were measured, and an apparent Young's modulus was calculated based on Hooke's law. On returning to its initial shape after the erythrocyte was released from stretching, the elapsed time and strain were measured, and a time constant for shape recovery was calculated based on the Kelvin model. The average apparent Young's modulus was 16.0Pa, and the average time constant was 113.4ms, with a slight tendency toward an inverse relation between the two physical quantities.
Journal
-
- Transactions of Japanese Society for Medical and Biological Engineering
-
Transactions of Japanese Society for Medical and Biological Engineering 53 (1), 1-7, 2015
Japanese Society for Medical and Biological Engineering
- Tweet
Details
-
- CRID
- 1390282680242735744
-
- NII Article ID
- 130005084160
-
- NII Book ID
- AA11633569
-
- ISSN
- 18814379
- 1347443X
-
- NDL BIB ID
- 026346196
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed