フェムト秒レーザによる表皮下微細構造のin vivo高分解能OCTイメージング

DOI Web Site 被引用文献2件 参考文献19件

書誌事項

タイトル別名
  • In Vivo Observation of Micro-tissue Structures by High-resolution Optical Coherence Tomography with a Femtosecond Laser
  • フェムトビョウ レーザ ニ ヨル ヒョウヒ カ ビサイ コウゾウ ノ in vivo コウ ブンカイノウ OCT イメージング

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説明

Optical coherence tomography (OCT) is very promising for high-resolution cross-sectional imaging underneath the surface of biological tissue. The axial resolution of OCT is determined by the coherence length of the light source used in a low-coherence interferometer. In this paper, we demonstrate high-resolution OCT of micro-tissue structures using a femtosecond Ti: sapphire laser. A coherence length of 3.1μm is obtained using a bulk optic interferometer. In the experiment, micro-skin structures including the epidermis, dermis and stratum basale are clearly observed using high-resolution OCT. In vivo high-resolution OCT of human skin was also successfully demonstrated. Furthermore, the thickness of the stratum corneum can be measured as near as 20μm using our OCT system. Our experimental results indicate that a femtosecond laser is suitable for high-resolution OCT for basic research in dermatology.

収録刊行物

  • 生体医工学

    生体医工学 42 (4), 404-410, 2004

    公益社団法人 日本生体医工学会

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