An Analog-Digital Hybrid Model of Electrical Excitation in a Cardiac Ventricular Cell

DOI Web Site 参考文献12件
  • MAHMUD Farhanahani
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
  • SAKUHANA Takashi
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University
  • SHIOZAWA Naruhiro
    College of Business Administration, Ritsumeikan University
  • NOMURA Taishin
    Department of Mechanical Science and Bioengineering, Graduate School of Engineering Science, Osaka University The Center for Advanced Medical Engineering and Informatics, Osaka University

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説明

Contraction of the heart is controlled by electrical excitations of cardiac cell membranes. The electrical excitations of the cells and their propagation within the heart tissue provide a basis of the physiological function of the heart through the cardiac excitation-contraction coupling mechanism. A large number of studies have been carried out using mathematical models of the cardiac excitation in order to understand normal and abnormal dynamics of the heart. However, simulating the dynamics of a tissue or organ model with a large number of cellular models requires an immense amount of computational time. Here, in order to reduce the computational time required for the simulation, we developed an analog-digital hybrid model of the electrical excitation of cardiac cells based on Luo-Rudy phase I (LR1) model for the action potential generation in a mammalian cardiac ventricular cell. The hybrid model includes analog circuits and a dsPIC microcontroller that could reproduce time-dependent and time-independent nonlinear current-voltage characteristics of six-type of ionic currents in LR1 model. The analog circuits were used to implement the ionic currents either of timeindependent or with relatively short time constants, and the dsPIC was used to implement the ionic currents with long time constants, connecting in parallel with a model of the membrane capacitance. The constructed model could realize real-time simulation of the action potential generation that was quantitatively comparable with the cardiac excitation of LR1 model. In particular, we showed that response characteristics of the hybrid model to periodic trains of impulsive current stimulation were also comparable with those of LR1 model.

収録刊行物

  • 生体医工学

    生体医工学 47 (5), 428-435, 2009

    公益社団法人 日本生体医工学会

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