Closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock
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- Uemura Kazunori
- Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
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- Kawada Toru
- Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
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- Zheng Can
- Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
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- Li Meihua
- Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
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- Sugimachi Masaru
- Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
Bibliographic Information
- Other Title
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- 敗血症性ショックにおける循環管理を支援する、コンピュータ制御自動循環蘇生システムの開発
Abstract
<p>Hemodynamic resuscitation in septic shock requires aggressive fluid replacements and appropriate use of vasopressors to optimize arterial pressure (AP) and cardiac output (CO). This is time/labor consuming task, because strict hemodynamic monitoring and repetitive adjustment of drug dose are required. To overcome this, we have developed a closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock, and validated performance of the system in 8 dogs with endotoxin shock. Our system computes arterial resistance (R) and stressed blood volume (V) from AP and CO. Our system controls R with noradrenaline, and V with Ringer's solution, thereby controlling AP and CO. Once activated in dogs with shock (AP=42±5 mmHg, CO=60±17 ml/min/kg), our system automatically restored AP to 70±2 mmHg and CO to 130±10 ml/min/kg within 40 min, and maintained them over 4 hours. We conclude that our system could be an attractive clinical tool in rescuing patients with septic shock.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering 55Annual (4AM-Abstract), 268-268, 2017
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390282680246251904
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- NII Article ID
- 130006076940
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed