Closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock

DOI
  • Uemura Kazunori
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
  • Kawada Toru
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
  • Zheng Can
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
  • Li Meihua
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center
  • Sugimachi Masaru
    Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center

Bibliographic Information

Other Title
  • 敗血症性ショックにおける循環管理を支援する、コンピュータ制御自動循環蘇生システムの開発

Abstract

<p>Hemodynamic resuscitation in septic shock requires aggressive fluid replacements and appropriate use of vasopressors to optimize arterial pressure (AP) and cardiac output (CO). This is time/labor consuming task, because strict hemodynamic monitoring and repetitive adjustment of drug dose are required. To overcome this, we have developed a closed-loop drug infusion system for automated hemodynamic resuscitation in septic shock, and validated performance of the system in 8 dogs with endotoxin shock. Our system computes arterial resistance (R) and stressed blood volume (V) from AP and CO. Our system controls R with noradrenaline, and V with Ringer's solution, thereby controlling AP and CO. Once activated in dogs with shock (AP=42±5 mmHg, CO=60±17 ml/min/kg), our system automatically restored AP to 70±2 mmHg and CO to 130±10 ml/min/kg within 40 min, and maintained them over 4 hours. We conclude that our system could be an attractive clinical tool in rescuing patients with septic shock.</p>

Journal

Details 詳細情報について

  • CRID
    1390282680246251904
  • NII Article ID
    130006076940
  • DOI
    10.11239/jsmbe.55annual.268
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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