Development of coherent anti-Stokes Raman scattering rigid endoscope for label-free nerve imaging during an operation
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- Hirose Keigo
- Graduate school of engineering science, Osaka University
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- Aoki Takuya
- Graduate school of engineering science, Osaka University
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- Fukushima Shuichiro
- Graduate school of engineering science, Osaka University
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- Sakaguchi Yoshiyuki
- Graduate school of engineering science, Osaka University
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- Furukawa Taichi
- Institute for NanoScience Design, Osaka University
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- Hashimoto Mamoru
- Graduate school of engineering science, Osaka University
Bibliographic Information
- Other Title
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- 術中での無染色神経イメージングを目指したコヒーレントアンチストークスラマン散乱硬性鏡の開発
Abstract
<p>We have developed a coherent anti-Stokes Raman scattering (CARS) rigid endoscope for label-free nerve imaging during an operation. The CARS rigid endoscope consists of a single-mode fiber which delivers two color lasers, a galvano scanning system, and homemade ϕ12 mm lens tubes which include two relay lenses and an objective lens. The label-free imaging of rat sciatic nerve is demonstrated. To attain CARS image with high- speed, correcting chromatic aberration is focused on. The split between the focal spots of two lasers passed through the lens tubes is 21 μm and a numerical simulation shows that the intensity of CARS signal by correcting the chromatic aberration is 2.3 times as strong as non-correcting. The rigid endoscope has been modified to suppress the chromatic aberration by using two single-mode fibers which deliver the two lasers individually. The experimental result shows the increase of CARS intensity at least 1.5 times.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering 54Annual (28PM-Abstract), S344-S344, 2016
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390282680246262272
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- NII Article ID
- 130005285405
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed