Role of mechanotransduction in angiogenesis
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- Fukuhara Shigetomo
- Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute
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- Yuge Shinya
- Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute
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- Kunita Itsuki
- International Research Center of Medical Sciences (IRCMS), Kumamoto University
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- Wakayama Yuki
- Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute
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- Nakajima Hiroyuki
- Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute
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- Nishiyama Koichi
- International Research Center of Medical Sciences (IRCMS), Kumamoto University
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- Mochizuki Naoki
- Department of Cell Biology, National Cerebral and Cardiovascular Center Research Institute
Bibliographic Information
- Other Title
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- 血管新生におけるメカノトランスダクション機構の役割
Abstract
<p>Angiogenesis, the formation of new blood vessels from pre-existing vasculature, regulates various physiological and pathophysiological processes. Here, we investigated the molecular mechanisms of angiogenesis by performing fluorescence-based bio-imaging analyses using zebrafish as a model animal and showed the potential role of intravascular pressure in regulation of angiogenesis. In severed blood vessels, the vessels located downstream of blood flow preferentially elongate to reconnect the damaged vessels comparing to the upstream vessels. Endothelial cell migration and proliferation actively occurred mainly in the downstream vessels. Since it is assumed that intravascular pressure is higher in the upstream vessels than in the downstream ones, these results suggest that intravascular pressure might regulate angiogenesis. Consistently, our preliminary in vitro data suggested that increased hydrostatic pressure inhibited vessel elongation in a 3D microfluidic angiogenesis model. These results suggest that hydrostatic pressure inhibits vessel elongation during angiogenesis by suppressing endothelial cell migration and proliferation.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering 54Annual (28PM-Abstract), S327-S327, 2016
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390282680246351104
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- NII Article ID
- 130005285419
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
