Introduction to BOLD fMRI

DOI

Bibliographic Information

Other Title
  • 機能的磁気共鳴画像（BOLD fMRI）の原理

Abstract

<p>Over the past 20 years, functional magnetic resonance imaging (fMRI) has been widely used to measure the brain activity. The primary form of fMRI uses the blood oxygenation level dependent (BOLD) contrast, in which hemoglobin in a red blood cell is used as an endogenous contrast agent, based on the difference in magnetic properties of oxyhemoglobin (diamagnetic) and deoxyhemoglobin (paramagnetic). In the physical basis, the presence of paramagnetic deoxyhemoglobin in blood vessels causes changes in the local magnetic field gradients that decrease MR signal. In the physiological basis, when neuronal activity increases, the blood flow increases to overcompensate the increased oxygen metabolism. The mismatch between the blood flow and the oxygen consumption leads to the paradoxical increase in MR signal with increased neuronal activity. In this tutorial lecture, we will explain the complex mechanism underlying the BOLD signal, which is needed to correctly interpret the fMRI data.</p>

Journal

Details 詳細情報について

  • CRID
    1390282680246604160
  • NII Article ID
    130006077040
  • DOI
    10.11239/jsmbe.55annual.357
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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