Analyzing the usefulness of the new anti-<I>Helicobacter pylori</I> serum antibody reagents: <I>H. pylori</I>-LATEX “SEIKEN”and <I>H. pylori</I> IgG “SEIKEN”

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  • GONDO Kenta
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
  • TAKAHASHI Yu
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
  • YAMAMICHI Nobutake
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
  • KAKIMOTO Hikaru
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo
  • WADA Ryoichi
    Kameda Makuhari Clinic
  • MITSUSHIMA Toru
    Kameda Makuhari Clinic

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Other Title
  • <I>H.pylori</I>診断におけるH.ピロリ─ラテックス「生研」及びH.ピロリIgG「生研」の有用性の検討
  • H.pylori診断におけるH.ピロリ-ラテックス「生研」及びH.ピロリIgG「生研」の有用性の検討
  • H.pylori シンダン ニ オケル H.ピロリ-ラテックス 「 セイケン 」 オヨビ H.ピロリ IgG 「 セイケン 」 ノ ユウヨウセイ ノ ケントウ

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Background and Aim: Helicobacter pylori (H. pylori) infection is the most important risk factor for gastric cancer. Serum anti-H. pylori antibody test among the diagnostic methods for H. pylori infection is widely used. The aim of this study was to compare the diagnostic accuracy of commercially available anti-H. pylori antibody reagents including the recently launched reagents.<BR>Method: Serum samples were collected from the subjects who underwent upper gastrointestinal barium X-ray radiography (UGI-XR) and upper gastrointestinal endoscopy (UGI-ES) within a year in a single medical institution, and analyzed using three commercially available anti-H. pylori antibody reagents: E-Plate Eiken H. pylori antibody (E-plate), H. pylori-LATEX “SEIKEN”(Denka Ltx), and H. pylori IgG “SEIKEN”(Denka EIA). We analyzed the diagnostic accuracy of these three reagents against H. pylori infection status determined with UGI-XR and UGI-ES.<BR>Result: A total of 902 subjects were analyzed. Considering UGI-ES based H. pylori infection status as a standard, sensitivity of E-plate was 83.3% and that of Denka Ltx and Denka EIA was 87.6% (P=0.0076) and 86.6% (P=0.0126) respectively. Considering both UGI-ES and UGI-XR based H. pylori infection status as a standard, sensitivity of E-plate was 89.5% and that of Denka Ltx and Denka EIA was 93.7% (P=0.0124) and 92.8% (P=0.0209), respectively. <BR>Conclusion: In diagnosing H. pylori infection, both Denka Ltx and Denka EIA demonstrated statistically significant higher sensitivity than E-plate.

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