TWO CASES OF CEREBRAL VESSEL DISEASE FOLLOWING HIGH DOSE INTRAVASCULAR IMMUNOGLOBULIN THERAPY

DOI 40 References

Bibliographic Information

Other Title
  • 免疫グロブリン大量点滴静注療法（ＩＶＩＧ）の関与が考えられる脳血管障害例

Search this article

Description

Background: Vascular injury, such as thrombotic complications, is known to occur as a side effect of high dose intravascular immunoglobulin therapy (IVIG therapy). Here, we report two cases of cerebral vessel disease.<br> Case 1: In September 2006, a 67-year old man, complicating of muscle insufficiency in the lower extremities, was diagnosed with sigmoid cancer and polymyositis with complicated aspiration pneumonia. Although antibiotic therapy for pneumonia, IVIG therapy for polymyositis, and surgical operative therapy for sigmoid cancer were performed, the patient died due to hemorrhage of the bilateral thalamus. <br> Case 2: In May 2006, a 62-year old man, who had previous history of pyoderma gangrenosum and myelodysplastic syndrome, suffered from fever and red blisters in the palm of his right hand. He was diagnosed with the recurrent pyoderma gangrenosum and necrotizing fasciitis. Although intensive therapy was performed using IVIG, antibiotics, mPSL pulse, and cyclosporine A, the patient died due to multiple cerebral infarction (right middle artery area, right posterior artery area, and cerebella area).<br> Discussion: Both cases show the possible difficulties of cerebral vessel complication in IVIG therapy. These observations suggest that further risk-value analysis is required to better assess cerebral vessel complications in IVIG therapy.<br>

Journal

References(40)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top