COMPARISON OF THE IN VITRO QUALITIES OF PLATELET CONCENTRATES SUSPENDED IN T-PAS+AND BICANATE COLLECTED WITH TRIMA ACCEL

DOI Web Site 2 Citations 19 References
  • Onodera Hidekazu
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Kaneko Yuji
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Koike Toshiyasu
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Miyajima Haruko
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Moriyama Rie
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Chatani Makoto
    Japanese Red Cross Kanto-Koshinetsu Block Blood Center
  • Nishitani Yumiko
    Tokyo Metropolitan Red Cross Blood Center
  • Hirayama Jyunichi
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Shibata Reiko
    Japanese Red Cross Kanto-Koshinetsu Block Blood Center Tokyo Metropolitan Red Cross Blood Center
  • Shiba Masayuki
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Nagai Tadashi
    Japanese Red Cross Blood Service Headquarters Central Blood Institute Japanese Red Cross Kanto-Koshinetsu Block Blood Center
  • Satake Masahiro
    Japanese Red Cross Blood Service Headquarters Central Blood Institute
  • Tadokoro Kenji
    Japanese Red Cross Blood Service Headquarters

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  • T-PAS＋<sup>Ⓡ</sup>またはビカネイト輸液を血小板保存液（PAS）として成分採血装置Trima Accelで採取したPAS置換血小板の品質の比較

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<p>Platelet concentrate suspended in Platelet Additive Solution (PAS) is a collection in which part of the plasma is replaced with PAS, and the residual plasma concentration is approximately 20% to 35% of the total volume. Platelet concentrate suspended in PAS (PAS-PC) is reportedly useful for decreasing the incidence of allergic side effects caused by transfusion. In this study, we investigated whether it is feasible to prepare PAS-PC using the blood component collection device Trima Accel. We collected ten platelet components, targeting a 200 ml final volume, 2.5×1011 total number of platelets per bag, and 35% residual plasma concentration. We obtained an average (range), volume of 197 ml (194-201 ml), a total platelet count of 2.69×1011/bag (2.49-3.00×1011/bag), and a residual plasma concentration of 35.0% (33.0-36.2%). Collection of PAS-PC according to the set goals was thus achievable. We examined the quality of PAS-PC collected from the same donor with the addition of either T-PAS+or Bicanate. The quality of the preparation was well maintained up until day 7 with T-PAS+. In contrast, the pH was more than 7.7 with Bicanate, which was higher than with T-PAS+, and glucose depletion was observed on day 7, and the number of platelets with spheroidal morphology was also higher.</p>

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