Examination of Clinical Efficacy of Keishibukuryogan on Non-Specific Complaints Associated with Varicose Veins of the Lower Extremity

  • Hayashi Shinobu
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Okubo Hirotoki
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Shibutani Shintaro
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Shimogawara Tatsuya
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Ichinose Tsuyoshi
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Ito Yasuhiro
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Egawa Tomohisa
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Mihara Kouki
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Nagashima Atsushi
    Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan
  • Obara Hideaki
    Department of Surgery, Keio University, Tokyo, Japan
  • Kitagawa Yuko
    Department of Surgery, Keio University, Tokyo, Japan

書誌事項

公開日
2014
DOI
  • 10.3400/avd.oa.14-00055
公開者
Annals of Vascular Diseases 編集委員会

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説明

The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (*English translation of Jpn J Phlebol 2013; 24: 303-310)

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