Control of Blood Vessel Identity: From Embryo to Adult

DOI 被引用文献3件 参考文献45件
  • Fancher Tiffany T
    Department of Surgery, Yale University School of Medicine Department of Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine Saint Mary's Health System
  • Muto Akihito
    Department of Surgery, Yale University School of Medicine Department of Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine
  • Fitzgerald Tamara N
    Department of Surgery, Yale University School of Medicine Department of Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine
  • Magri Dania
    Department of Surgery, Yale University School of Medicine Department of Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine
  • Gortler David
    Department of Pharmacology, Yale University School of Medicine
  • Nishibe Toshiya
    Fujita Health University
  • Dardik Alan
    Department of Surgery, Yale University School of Medicine Department of Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine VA Connecticut Healthcare System

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説明

Arteries and veins have been historically defined by the direction of blood flow and oxygen tension within the vessel, in addition to their functional, hemodynamic, and anatomical differences. It is now known that the molecular identity of these vessels is genetically predetermined, with specific molecular pathways acti-vated during the development of arteries and veins. Eph-B4 is a determinant of venous differentiation and Ephrin-B2 is a determinant of arterial differentiation. Placement of a vein into the higher pressure and flow of the arterial circulation results in adaptation of the vein to the arterial environment. There is selec-tive loss of Eph-B4 expression without induction of Ephrin-B2 expression during vein graft adaptation. These findings suggest that loss of venous identity is the crucial mechanism in vein graft adaptation and that developmentally critical determinants of vessel identity are plastic during adult life.

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