ホスホリパーゼＤの触媒するホスファチジル基転移反応による機能性リン脂質誘導体の合成

DOI Web Site 被引用文献2件 参考文献48件

書誌事項

タイトル別名
  • Synthesis of Pseudo-Phospholipids by Phospholipase D-Catalyzed Transphosphatidylation.
  • ホスホリパーゼ D ノ ショクバイスル ホスファチジルキ テンイ ハンノウ ニ

この論文をさがす

抄録

We found that phospholipase D from Streptomyces sp. (PLDP) effectively catalyzed transphosphatidylation, i.e., the regiospecific transfer of the phosphatidyl residue from phosphatidylcholines to alkanols. The scope of this enzymatic reaction was investigated in detail to develop an efficient method for preparing various phospholipid derivatives. Using this enzymatic method, 5'-Ο-phosphatidyl derivatives of antitumor nucleosides were successfully synthesized to identify potent antitumor drugs. 5'-Ο-Phosphatidyl derivatives of DMDC (2'-deoxy-2'-methylenecytidine) and CNDAC [1- (2-C -cyano-2-deoxy-β-arabino-pentofuranosyl) cytosine], antitumor nucleosides developed by us, showed significant antitumor effects in mice which clearly surpassed those of parent compounds. We have also demonstrated that 5'-Ο-phosphatidylnucleosides can be used as a drug delivery system for lymph : 5'-Ο-phosphatidyl-5-fluorouridine given orally is absorbed via the deacylation-reacylation cycle, a specific pathway for natural phospholipids, to be transported selectively to the lymph.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (48)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ