Chemistry of a Marine Depsipeptide, Hapalosin, and Its Reversing Activity against the P-Glycoprotein-mediated Multidrug Resistance.
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- Nishiyama Shigeru
- Department of Chemistry, Faculty of Science and Technology, Keio University
Bibliographic Information
- Other Title
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- 多剤耐性癌克服活性を有するデプシペプチド海洋天然物ハパロシンの化学と生物活性
- タザイ タイセイガン コクフク カッセイ オ ユウスル デプシペプチド カイヨウ テンネンブツ ハパロシン ノ カガク ト セイブツ カッセイ
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Description
Hapalosin isolated from Hapalosisiphon welwitschii W. & G. S. West, is a cyclic depsipeptide carrying the reversing activity against multidrug-resistance (MDR) of cancer cells acquired during chemotherapy. The 12-membered-ring structure that consists of 2-hydroxy-3-methylbutanoic acid, 3-hydroxy-2-methyldecanoic acid, and 3-hydroxy-4-(methylamino)-5-phenylpentanoic acid, adopts a 3:1 mixture of conformers related to the amide residue. From biological and stereochemical points of view, many research groups have challenged this intriguing target. This review discloses chemical investigations of hapalosin and related derivatives, as well as their biological activities.
Journal
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- Journal of Synthetic Organic Chemistry, Japan
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Journal of Synthetic Organic Chemistry, Japan 59 (10), 938-947, 2001
The Society of Synthetic Organic Chemistry, Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282680254073856
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- NII Article ID
- 10012286418
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- NII Book ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL BIB ID
- 5937573
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed