書誌事項
- タイトル別名
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- Stereocontrolled Synthesis of Nucleosides Based on Intramolecular Glycosylation Strategy.
- ブンシ ナイ グリコシルカ ハンノウ オ キバン ト スル ヌクレオシドルイ ノ リッタイ センタクテキ ナ ゴウセイ
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A convenient method for the stereocontrolled synthesis of nucleosides has been developed utilizing intramolecular aglycon delivery system. An important feature is to use 1-thioglycosides as glycosyl donor substrates, which can be counted as stable glycosides during modification steps of the carbohydrate moieties as well as introduction step of the pyrimidine base, but, on the other hand, the 1-thioglycosides can work as powerful glycosyl donors when they are treated with an appropriate thiophilic reagent. The suitable activator was found to be Me2S(SMe)BF4. The synthetic applicability is demonstrated by the syntheses of pharmaceutically important deoxynucleosides exemplified as ddC, AZT, FLT, some base-modified nucleosides, isonucleosides, nucleoside antibiotics, and 4'-thionucleosides.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 59 (9), 879-891, 2001
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680254187776
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- NII論文ID
- 10012287248
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 5905538
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可