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- 砂塚 敏明
- 北里大学薬学部 北里研究所
書誌事項
- タイトル別名
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- The Efficient Total Synthesis of Bioactive Microbial Natural Products.
- ビセイブツ ユライ セイブツ カッセイ テンネンブツ ノ コウリツテキ ナ ゼンゴウセイ
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We have been working on finding new bioactive microbial metabolites at the Kitasato Institute. Their microbial natural products have a variety of unique and complex skeletones with many chiral centers and functional groups, and biological activities. We also have been working on total synthesis of them, which is effective and concise convergent approach, designed to afford easy access to both the natural products and a variety of analogs to clarify the structure-activity relationships. We have succeeded the efficient total syntheses of bioactive microbial metabolites; pyripyropene A (1) and E, arisugacin (2), paspalicine (3) and paspalinine (4), lactacystin (5), macrosphelide (6), and madindoline (7). We also have succeeded to create better analogs of pyripyropene A (1) and lactacystin (5).
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 58 (9), 828-838, 2000
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680254196096
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- NII論文ID
- 10008821531
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BD3cXmtlKgt74%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 5474695
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可