書誌事項
- タイトル別名
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- Asymmetric Total Synthesis of Epolactaene.
- エポラクタエン ノ フセイ ゼンゴウセイ
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抄録
A total synthesis of the neuritegenic agent, epolactaene has been achieved via a convergent approach in 14 steps from optically active lactaldehyde derivatives. The key steps include (i) the stereoselective aldol reaction between malonate ester enolate and α-alkoxy aldehyde (ii) diastereospecific lactonization of malonate ester (iii) E-selective Wittig reaction. The optical rotation was identical with that of the natural (+) -epolactaene, which establishes that the absolute configuration of natural (+) -epolactaene is (13R, 14R) definitively. Other several epoxy-γ-lactam compounds also synthesized which suggest this method would be general for organic synthesis.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 58 (3), 183-191, 2000
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680254816384
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- NII論文ID
- 10008819273
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- NII書誌ID
- AN0024521X
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 5301703
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可