Skull base surgery for malignant nasal and paranasal tumors

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  • 当科における鼻副鼻腔悪性腫瘍の頭蓋底進展例に対する手術療法の検討

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Abstract

Objective: Skull base surgery for malignant tumors is a standard procedure. We performed skull base operations depending on the extent of the skull base range with the basic policy that tumor resection is feasible in an en bloc fashion with negative histological margins.<br>Methods: Forty-seven patients at Aichi Cancer Center were analyzed for outcomes from January 1, 2000 to December 31, 2009. The median age was 57 years (range 22-78 years). The majority of tumors(52%) involved the anterior-middle cranial fossa. Maxillary sinus (74%) was the most common primary site, and squamous cell carcinoma (66%) was the most common histologic type.<br>Results: Postoperative complications were reported in 17 patients (35.4%), with CSF leakage 8.3%. The postoperative mortality rate was 4.1%. With a median follow-up of 40 months, the 5-year overall, disease-specific, and disease-free survival rates were 59.8%, 61.1%, 57.6% respectively. The status of surgical margins is an independent determinant of outcome.<br>Conclusion: Skull base surgery is a safe and effective treatment option for patients with malignant nasal and paranasal tumors of the skull base.<br>The status of surgical margins is an independent determinant of outcome.

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