Superselective intra-arterial infusion chemotherapy administered through the deep lingual artery and concomitant radiotherapy

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  • Tomidokoro Yuichi
    Department of Otolaryngology-Head and Neck Surgery, Ehime Prefectural Central Hospital
  • Honda Nobumitsu
    Department of Otolaryngology-Head and Neck Surgery, Ehime Prefectural Central Hospital
  • Mitani Sohei
    Department of Otolaryngology-Head and Neck Surgery, Ehime Prefectural Central Hospital
  • Takagi Taro
    Department of Otolaryngology-Head and Neck Surgery, Ehime Prefectural Central Hospital
  • Nishihara Eriko
    Department of Otolaryngology-Head and Neck Surgery, Ehime Prefectural Central Hospital
  • Nakamura Koshiro
    Department of Otolaryngology-Head and Neck Surgery, Ehime Prefectural Central Hospital
  • Ugumori Toru
    Department of Otolaryngology-Head and Neck Surgery, Ehime University School of Medicine

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Other Title
  • 当科における進行舌癌に対する放射線療法併用超選択的動注化学療法
  • ―舌深動脈からの動注―

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Between January 2008 and January 2012, 11 patients with locally advanced squamous cell carcinoma of the tongue underwent superselective intra-arterial infusion chemotherapy and concomitant radiotherapy at our hospital. Their characteristics were as follows: mean age 65 years old, 3 males and 8 females. Four patients were clinical stage III and 7 patients were clinical stage IV. T stages included T2 (3 cases), T3 (6), and T4a (2), and N stages included N0 (3 cases), N1 (3), and N2 (5). We administered superselective intra-arterial chemotherapy using the Seldinger technique combined with radiotherapy in the 11 patients. In five patients, the drugs were administered through the deep lingual artery. The local control rate for the primary site and the neck were 81.8% and 100%, respectively. Disease-specific 3-year survival rate was estimated by Kaplan-Meier's method to be 100%. These findings suggest that superselective intra-arterial chemotherapy through the deep lingual artery combined with concomitant radiotherapy is a safe and effective treatment not only for the primary site but also for cervical lymph node metastases.

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