体積および圧縮率から見たアミロイド線維

DOI

書誌事項

タイトル別名
  • Volume and Compressibility of Amyloid Fibrils

抄録

Intrinsically unfolded hen lysozyme disulfide-deficient variant spontaneously forms amyloid-like fibrils. Its early assembly reversibly dissociates under high hydrostatic pressure with a partial molar volume decrease of 100 mL per monomeric unit. The partial specific volumes of the monomeric and protofibrillar states are 0.684 and 0.724 mL g-1, respectively, and the adiabatic compressibility coefficient of these states are -7.48 and 1.35 Mbar-1, which indicates that the protofibrillar state is highly voluminous and compressible. Pressure accelerates the dissociation of protofibrils with a negative activation volume of -50 ml mol-1 and a negative activation compressibility of -0.013 ml mol-1 bar-1, which suggests that partial hydration of existing voids takes place in the transition state of dissociation reaction.

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詳細情報 詳細情報について

  • CRID
    1390282680263170176
  • NII論文ID
    130004503878
  • DOI
    10.11229/hpbb.2.15
  • ISSN
    18821723
  • データソース種別
    • JaLC
    • CiNii Articles
    • KAKEN
  • 抄録ライセンスフラグ
    使用不可

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