Improvement of Cancer Cachexia with Chemothermotherapy in a Patient with Advanced Pancreatic Cancer

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  • 温熱化学療法が有効であった癌悪液質を伴った末期膵癌の一例

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The ultimate goal of cancer treatment is to achieve a complete eradication of the cancer. However, patients with terminal cancer are also treated to obtain an improvement in their quality of life (QOL).<BR> In this report, we describe the dramatic response of an end-stage pancreatic cancer patient with cachexia to a combination of hyperthermia (HT) and chemotherapy (CH). The patient was treated with a combination of intermittent 5-FU/cisplatin (CDDP) therapy and HT. Three months later, the local recurrent cancer had disappeared, the liver metastases were reduced by 80%, the lung metastatic lesion was markedly reduced, tumor markers had returned to normal, and the cachexia had been almost reversed. Performance status (PS) improved from 4 to 1, QOL improved, and the patient survived until his 258th hospital day.<BR> In this patient, the combination of CH and HT was useful not only for improvement of cachexia, but also for tumor reduction. A possible mechanism leading to this effect is discussed.

Journal

  • Thermal Medicine

    Thermal Medicine 23 (4), 159-170, 2007

    Japanese Society for Thermal Medicine

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