鉄欠乏性貧血がラットの成長に及ぼす影響

DOI

書誌事項

タイトル別名
  • Effects of lron Deficiency Anemia on Growth Rate of Rats

抄録

We conducted two experiments to investigate the effects of iron deficiency anemia on growth rate. In Experiment I, the iron-deficient group received a diet with 3.6 ppm iron citrate and the control group received a diet with 303 ppm iron citrate. Pair-fed rats received a control diet in amounts equivalent to that consumed by the iron-deficient group. Experiment 2 included an additional iron-deficient control (IDC) group that received the iron-deficient diet for six weeks followed by three weeks of the control diet. Growth associated with a decrease in food intake was significantly retarded in the iron-deficient and pair-fed rats than control rats. However, the ratio of daily diet intake to growth in the iron-deficient group was more than that of the control groups. The plasma leptin concentration in the iron-deficient group was significantly lower than the pair fed group in Experiment 1. We could not fmd that iron-deficient rats have a poor appetite and increase the plasma leptin level. In experiment 2, the iron-deficient status of the IDC group resulted in poor growth, hyperlipidemia and anemia, but their growth increased by the end of the experiment. The plasma leptin concentration (ng/ml) in the control, iron-deficient and IDC groups was 1.37±0.27, 0.90±0.14, and 2.12±0.53, respectively. The leptin concentration in the control and IDC groups, but not in the iron-deficient group, was siginificantly correlated with fat weight. Our results suggest that decreased growth rate may be due to malnutrition of the iron-deficient diet, and the effect of increased energy consumption. The decreased leptin concentration and the lack of a significant correlation between leptin concentration and fat weight in the iron-deficient rats may be necessary to maintain growth.

収録刊行物

  • 形態・機能

    形態・機能 7 (2), 67-75, 2009

    コ・メディカル形態機能学会

詳細情報 詳細情報について

  • CRID
    1390282680264212480
  • NII論文ID
    130004185380
  • DOI
    10.11172/keitaikinou2002.7.67
  • ISSN
    18846084
    13477145
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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