Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids

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  • SHIROSAKI Yuki
    Graduate School of Natural Science and Technology, Okayama University
  • TSURU Kanji
    Faculty of Dental Science, Kyushu University
  • MORIBAYASHI Hirofumi
    Graduate School of Natural Science and Technology, Okayama University
  • HAYAKAWA Satoshi
    Graduate School of Natural Science and Technology, Okayama University Research Center for Biomedical Engineering, Okayama University
  • NAKAMURA Yuri
    Faculty of Engineering, Okayama University
  • GIBSON Iain R.
    Institute of Medical Sciences, University of Aberdeen Department of Chemistry, University of Aberdeen
  • OSAKA Akiyoshi
    Graduate School of Natural Science and Technology, Okayama University Research Center for Biomedical Engineering, Okayama University

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  • Preparation of osteocompatible Si(4)-enriched chitosan-silicate hybrids

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Abstract

Chitosan–γ-glycidoxypropyltrimethoxysilane (GPTMS)–tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol–gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan–GPTMS–TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture.

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